Kinases
Kinases are enzymes that catalyze the transfer of phosphate groups from phosphate-donating molecules to substrates. This process is known as phosphorylation, where the substrate gains a phosphate group and the donating molecule loses a phosphate group. Substrate acceptors may be small organic molecules such as glucose or macromolecules such as proteins, and the phosphorylated acceptor molecule may be more or less active than the non-phosphorylated form. Kinases are widely involved in signal transduction pathways and control complex cellular functions.
Antimicrobial peptides
Cat No. | Product Name | Activity |
---|---|---|
AM-050 | Melittin (synthetic) | Haemolytic component of honey bee venom |
Biotin labelled peptides
Cat No. | Product Name | Activity |
---|---|---|
KS-071 | Crosstide, biotinylated | Akt/PKB (protein kinase B) substrate |
BT-010 | pFYN peptide | Phosphorylated peptide substrate derived from FYN, a Src family kinase |
Cell penetrating peptides
Cat No. | Product Name | Activity |
---|---|---|
PP-220 | F1 | Blocks the association of IKKbeta and NEMO |
KS-230 | MMI 0100 | MAPK-activated protein kinase II inhibitor |
AS-010 | NT1–20 | Blocks ASIC1a binding to RIPK1 |
KS-110 | PKI (14-22) amide, myristoylated | Cell permeable protein kinase A inhibitor |
KS-200 | st-Ht31 | AKAP-PKA interaction inhibitor |
KS-220 | Tat-braftide | Allosteric BRAF inhibitor |
Peptides
Cat No. | Product Name | Activity |
---|---|---|
PL-030 | AtPep1 | Plant elicitor peptide |
KS-190 | Autocamtide-2-related inhibitory peptide | CaM kinase II inhibitor |
PP-170 | Caveolin-1 scaffolding domain peptide | The binding domain of caveolin-1 |
PL-020 | elf18 | Inducer of defence responses |
KS-350 | Leptin-1 | AMPK, PI3K and AKT activator |
NR-220 | MDANP | PERK-eIF2ɑ-QRICH1 pathway modulator |
KS-180 | MLCK inhibitor peptide 18 | Selective inhibitor of myosin light chain kinase |
KS-210 | MOTS-c | AMPK activator |
KS-240 | Octpep-1 | Targets PI3K/AKT/mTOR signaling |
PL-010 | PEP7 | Endogenous ligand for the receptor kinase SIRK1 |
KS-060 | PKA inhibitor (6-22) amide | cAMP-dependent protein kinase (PKA) inhibitor |
KS-050 | PKI (5-24) | cAMP-dependent protein kinase A (PKA) inhibitor |
KS-120 | R18 | 4.3.3 proteins antagonist |
PP-440 | RMR | Disrupts PAK1–RUNX3 interaction |
KS-170 | ZIP | Protein kinase Mζ inhibitor |
Small molecules
Cat No. | Product Name | Activity |
---|---|---|
KS-290 | A 769662 | AMPK activator |
KS-260 | CHIR 99021 | GSK3 inhibitor |
KS-280 | Dibutyryl-cAMP, sodium salt | PKA activator |
KS-300 | Dorsomorphin | AMPK inhibitor |
KS-330 | Go 6983 | PKC inhibitor |
CV-040 | Nelfinavir mesylate | Human immunodeficiency virus (HIV)-1 protease inhibitor |
KS-310 | PD 325901 | MEK inhibitor |
KS-320 | Staurosporine | Broad spectrum kinase inhibitor |
KS-270 | Torin 1 | mTOR inhibitor |
KS-340 | U0126 | MAPK inhibitor |
KS-250 | Y 27632 dihydrochloride | Rho-associated protein kinase (ROCK) inhibitor |
Substrate peptides
Cat No. | Product Name | Activity |
---|---|---|
KS-160 | Abl substrate peptide | Substrate for Abl kinase |
KS-040 | Akt substrate | Substrate for Akt |
KS-001 | AMARA Peptide | Substrate for all AMPK subfamily kinases |
KS-070 | Crosstide | Akt/PKB (protein kinase B) substrate |
KS-080 | EGF receptor (651-658) | Protein kinase C (PKC) substrate |
KS-081 | EGF Receptor (651-658), myristoylated | Protein kinase C (PKC) substrate, membrane permeant |
KS-030 | Kemptide | cAMP-dependent protein kinase (PKA) substrate |
KS-010 | LRRKtide | Leucine rich repeat kinase 2 (LRRK2) substrate |
KS-140 | MBP (4-14) | Highly selective substrate for protein kinase C (PKC) |
SP-030 | Phospho glycogen synthase peptide 2 | Glycogen synthase kinase 3 (GSK 3) substrate |
KS-150 | PKCδ substrate | Protein kinase C δ (PKCδ) substrate |
SP-050 | Rad17 derived peptide | ATR kinase substrate |
SP-040 | RS repeat peptide | Dual specificity protein kinase CLK1 substrate |
KS-020 | SAMS Peptide | AMP activated protein kinase (AMPK) substrate |
SP-020 | Ziptide | Zipper interacting protein kinase (ZIPK) substrate |
KS-100 | [Ala97]-RII (81-99) | Protein kinase A (PKA) substrate |
KS-090 | [Ser159]-PKCε (149-164) | Protein kinase C epsilon (PKCε) pseudosubstrate |
Further reading
Manning et al (2002) The protein kinase complement of the human genome. Science 298(5600) 1912 PMID: 12471243
Berndt et al (2017) Advances of small molecule targeting of kinases, Curr. Opinion Chem. Biol. 39 126 PMID: 28732278
Deng et al (2019) Essential Kinases and Transcriptional Regulators and Their Roles in Autoimmunity. Biomolecules 9(4) 145 PMID: 30974919
Ayala-Aguilera (2022) Small Molecule Kinase Inhibitor Drugs (1995-2021): Medical Indication, Pharmacology, and Synthesis. J Med Chem. 65(2) 1047 PMID: 34624192
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