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Latest News

BIOHUB INTERNATIONAL 上海起发实验试剂有限公司 - New distributor for China

Published on May 3rd 2022

Isca Biochemicals products can now be obtained through BIOHUB INTERNATIONAL - our new distributor for China. Headquartered in Pudong, Shanghai, PR China, BIOHUB have become the first choice for biological reagents in China with more than 10 years experience offering antibodies, kits, proteins and media, as well as providing a rich marketing experience and supporting over 2000 sub distributors and 5000 customers in China. With BIOHUBs uniqueknowledgeof their Chinese customers and markets and fir...


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PD-1/PD-L1 interaction inhibitors

Published on April 5th 2022

Programmed cell death protein 1 (PD-1) plays a vital role in inhibiting immune responses and promoting self-tolerance through modulating the activity of T-cells, activating apoptosis of antigen-specific T cells and inhibiting apoptosis of regulatory T cells. Programmed cell death ligand 1 (PD-L1) is a trans-membrane protein co-inhibitory factor of the immune response, whichcan combine with PD-1 to reduce the proliferation of PD-1 positive cells, inhibit their cytokine secretion and induce apopto...


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Therapeutic peptides review

Published on March 8th 2022

Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and delivery strategies, which have helped to overcome the inherent drawbacks of peptides and have allowed the continued advancement of this field. A wide variety of natural and modified peptides have been obtained and studied, covering multiple therape...


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BIOZOL - new distributor for Germany, Switzerland and Austria

Published on February 14th 2022

Isca Biochemicals products can now be obtained through BIOZOL - our new distributorfor Germany,Switzerland and Austria. Headquartered in Eching, Germany, BIOZOL provide more than 25 million products from more than 220 partner companies around the world, a service which is completed by the BIOZOLcustomer support team of scientists with many years of research experience. More than 14,000 customers from universities, research institutes andpharmaceuticaland biotech companiesbenefit from30 years o...


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First new peptide for 2022

Published on January 6th 2022

Happy new year to all our customers - and here is our first new peptide of2022,NT1–20, a tatylated membrane penetrating peptidederived from the N-terminus of the acid sensing ion channel 1a (ASIC1a), which can block the binding ofASIC1a to receptor interacting protein kinase 1 (RIPK1) atits C terminus. ASIC1 is alow pH activated Na+ permeable ion channel whichmediates necroptosis via recruiting RIPK1, independent of its ion-conducting function, and though this mechanism NT1-20 protects neurons...


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Christmas opening hours

Published on December 20th 2021

During the festive period we will be closed from thursday the 23rd of December to tuesday the 4th of January, and while there may be someone in the lab and we will be able to receive orders, we will not be able to ship anything until the end of the holidays. We would like to wish all of our customers a very happy christmas and a prosperous new year and we look forward to seeing you all in 2022....


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2B Scientific - new agent for the UK and Ireland

Published on December 7th 2021

Isca Biochemicalsproducts can now be obtainedthrough 2B Scientific in the UK and Ireland. Headquarteredin Oxfordshire, UK, 2BScientific is reinventing the supply of immunological reagents and kits to the European research market with their easy purchase process, presence on customer procurement portals and 100% quality guarantee. 2BScientific's mission is to become the leading supplier of innovative life science reagents and services to the European research market in a way that supports life sc...


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Sortase reagents

Published on November 4th 2021

Protein-sorting transpeptidases are enzymes that cleave target proteins produced by the same cell, as part of a specialized pathway of protein targeting. Protein-sorting transpeptidases transferthe N-terminal portion of the cleaved polypeptide into another molecule. The term sortase is correctly reserved for the cysteine protease enzymes sortase A, sortase B, and members of additional classes, all of which share homology. We now offer the sortase recognition sequence, LPETGG, coupled to the flu...


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Orexin receptor peptides

Published on October 18th 2021

Orexins (hypocretins) are a family of neuropeptides consisting of two members, orexin A and orexin B, which are produced from a common precursor prepro-orexin. The orexins activate two G-protein-coupled receptors (OX1 and OX2), bothfound predominantly in the hypothalamus. Orexin A is the selective endogenous agonist for OX1 and blocking this receptor modulates food and water intake. Orexins are also linked to the regulation of sleep-activity cycles. Isca now have the key orexin peptidesin one...


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New product page

Published on September 9th 2021

New products are an essential part of our rangeand we make novel introductions continuously,resulting in many new peptides and biochemicalsbeing added every year. Our aim is to find the latest research tools and bring them to researchers as rapidlyas we can, and to help identify them our new products can now be seen in one place on a dedicated new products pageIf you can'twhat you are looking for, we welcome suggestions for new productsand our customsynthesis teamare always on hand to makelarge...


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New range of PAR receptor ligands

Published on August 10th 2021

Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors which are activated by cleavage of their N-terminal domains by serine proteases. Cleavage produces a tethered peptide ligand, which influences transmembrane signaling. Four subtypes of receptors been cloned (PAR1-4). PAR1 is the most well characterized member of this receptor family and is activated by the endogenous serine protease thrombin. PAR1 activation has been implicated in cardiovascu...


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Distributors in the USA and Canada, India and Japan

Published on July 7th 2021

We are pleased to announce that we have three new distributors for our products, covering the territories ofthe USA and Canada, India and Japan. Customers in the UK, Europe and the rest of the world can continue to use the Isca office in the UK and bear in mind that we have now made European shipping free indefinitely. The full list of distributor contact details is as follows:UK, Europe and the rest of the worldIsca Biochemicals 26 Hanover Road Exeter EX1 2TL Phone: +44 (0)1392 422205 Fax:...


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Free catalogue peptide shipping in the UK and Europe

Published on July 2nd 2021

Free catalogue peptide shipping from our Exeter office has now been extended indefinitely throughout the UK and Europe. For any other territory we will endeavour to keep delivery charges as low as possible. Please contact us for more information about shipping charges to countries not specified....


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New antifungal peptoids from MTSU

Published on June 11th 2021

Isca are pleased to announce three novel lipopeptoids with potent antifungal activity, licensed from Middle Tennessee State University. Theseare AEC5, which rapidly reduces fungal burden in infected macrophages against C. neoformanswith complete elimination of viable fungi within 3 hours, and the optimised derivatives β-5and γ-2which have improved potency anddecreased toxicity. In mouse models AEC5 has an in vivo half-life of >20 hours and no observable toxicity following 28 days of daily i...


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Peptides for neuropeptide Y research

Published on June 4th 2021

Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes, Y1, Y2, Y4 and Y5. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. Neuropeptide Yreceptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituita...


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PACAP receptor peptide section

Published on May 4th 2021

PACAP (Pituitary adenylate cyclase-activating polypeptide) receptors are Gs-protein-coupled receptors referred to as PAC1, with an endogenous ligand, PACAP, that also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the central nervous system, including theolfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum as well as in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biolo...


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External peptide resources

Published on April 7th 2021

We needed a place to find our favourite peptide resources links so we have collected up the following pages in one place as external peptide resourcesand we hope that people will find it as useful as we do. Please let us have any suggestions for any other peptide resourcesthat should be here.ProtParamcan determine physical and chemical parameters for a given protein in Swiss-Prot or TrEMBL or for a user entered sequence. Parameters include molecular weight, theoretical pI, amino acid composition...


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New synuclein knockdown peptide

Published on March 5th 2021

Tat-βsyn-degronis a blood brain barrier and plasma membrane permeable α-synuclein knockdown peptide which can reducethe level of α-synuclein byproteasomal degradation. Tat-βsyn-degron decreasesα-synuclein aggregates and microglial activation in an α-synuclein preformed fibril model of spreading synucleinopathy in transgenic mice overexpressing human A53T α-synuclein, and reducesα-synuclein levels and significantly decreasesthe neuronal damage and motor impairment in a mouse toxicity mode...


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New website launched

Published on March 4th 2021

The newIsca Biochemicals website went live today. It is designed to be as informative and user friendly as possible, withproducts are now grouped for browsing by pharmacology, product type or research application for easy identification. The new search facility allows searches by product name, or partial name, sequence, or partial sequence, andCAS number. We have added a section of external peptide links and ordering online has been introduced and the process greatly simplified. We hope our new ...


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Free catalogue peptide shipping in March

Published on March 1st 2021

Free catalogue peptide shipping is extended into Marchfor all UK and European customers. Please quote Mar2021 on your order...


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New citations for LL 37 and Parasin I

Published on December 3rd 2020

Antimicrobial peptides, or host defence peptides, are active against bacteria, viruses, microscopic fungi and protozoa. Two new publications, from the University of Leipzig and the University of Helsinki have recently made use of LL 37, the host defence peptide derived from the human cathelicidin antimicrobial peptide hCAP18, and Parasin I, the amphipathic antimicrobial peptide derived from histone H2A of the catfish. The Leipzig group have show the activity of both peptides against periodonta...


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Novel peptidomimetic probes for NTMT1/2

Published on September 22nd 2020

Protein N-terminal methyltransferases (NTMTs) methylate the α-N-terminal amines of proteins starting with the canonical X-P-K/R motif. Genetic studies imply that NTMT1 regulates cell mitosis and DNA damage repair. Isca Biochemicals are pleased to announce the availability of first potent peptidomimetic inhibitors for NTMT1/2, BM30, a competitive inhibitor to the peptide substrate but noncompetitive to the cofactor S-adenosylmethionine, and the analogue DC432 which is BM30 made cell permeable by...


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New range of pain regulatory peptides

Published on September 10th 2020

Isca Biochemicals is pleased to announce that a new range of pain regulatory peptides is now available. Our new range contains a mixture of research standards and exclusive peptides that act on established pain targets such as neurokinin 1 (NK1), bradykinin (B1 and B2),the nociceptin receptor (NOP, ORL-1),inward rectifier K+ channels,sensory neuron specific receptors (SNSRs), connexin43 hemichannels,transient receptor potential ion channels TRPA1 and TRPV1, the interaction of the axonal collapsi...


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New appetite regulatory peptides available

Published on August 14th 2020

Ghrelin (rat)(GH-180) and ghrelin (human)(GH-190), the endogenous agonists for the rat and human ghrelin receptors are now available from Isca Biochemicals. Ghrelin is produced by the stomach, and is linked to inducing appetite and feeding behaviour, and is a key component of the appetite control sytem that originates from the hypothalamus. In addition to these new ghrelins, Isca Biochemicals offers a range of appetite regulatory peptides acting on the key components of the appetite control syst...


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Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205Fax: (+44) 01392 279510
[email protected]

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

[email protected] 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : [email protected]


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: [email protected]


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: [email protected]


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: [email protected]


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: [email protected]

India
Biotechno Labs
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: [email protected]


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email: [email protected]


All distributors >