Receptor serine/threonine kinase receptors

Receptor serine/threonine kinases (RSTKs) are a group of related catalytic receptors that includes TGF-β receptors (TGF-βRI-III) and activin receptors (ALK1-7).  RSTKs exist as heterodimers of type I and type II receptors and the ligand binding domain is located in the type II receptor.  Upon ligand-receptor binding, the type I receptors are recruited to the complex and are phosphorylated by the type II receptor.  Many human diseases are caused by dysregulation of RSTK signaling, including gastrointestinal, pancreatic and pituitary malignancies.

Further reading

Josso and di Clemente (1997) Serine/threonine kinase receptors and ligands. Curr. Opin. Genet. Dev. 1997 7(3) 371 PMID: 9229113

Botello-Smith et al (2017) Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock. PLoS Comput. Biol. 13(8) e1005711 PMID: 28827795

Chaplin et al (2017) Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors. J. Cell Commun. Signal. 11 117 PMID: 28168348