Search
0
Items
Select
Search
MENU
Select

Nuclear receptor modulators

Nuclear receptors are a family of ligand-regulated transcription factors that are activated by one of two main classes of ligands, steroid hormones - such as estrogen and progesterone - and non steroidal ligands, including retinoic acid and thyroid hormone.  A number of nuclear receptors have no known endogenous ligands and are considered orphan receptors, these include FXR, LXR, and PPAR.  Instead these receptors bind with low affinity to a number of metabolic intermediates and may function as metabolic sensors.  A unique property of nuclear receptors is their ability to directly interact with and regulate transcription of genes, which allows them to control a wide variety of biological processes, such as the cellular response to sex steroids, vitamin D3, adrenal steroids and other metabolic ligands.
Biotin labelled peptides
Cat No. Product Name Activity
PP-020 SRC-1 (676–700), biotinylated Biotinylated peptide derived from the transcriptional coregulatory protein human nuclear receptor coactivator SRC-1
Cell penetrating peptides
Cat No. Product Name Activity
PP-220 F1 Blocks the association of IKKbeta and NEMO
PP-270 TAT-ANK Dll4-Notch1 inhibitor
PP-260 Tat-NTS peptide

Blocks the interaction of ANXA1 with importin β

Peptides
Cat No. Product Name Activity
CK-020 HBP08 CXCL12/HMGB1 heterocomplex inhibitor
PP-240 NFAT Inhibitor

Calcineurin-NFAT interaction inhibitor

NR-180 S9pep SOX9 mimetic

Robinson-Rechavi et al (2003) The nuclear receptor superfamily.  J. Cell Sci. 116: 585 PMID: 12538758

Sever and Glass (2013) Signaling by nuclear receptors. Cold Spring Harb. Perspect. Biol. 5(3) a016709 PMID: 23457262

Alexander et al (2019) The Concise Guide to PHARMACOLOGY 2019/20: Nuclear hormone receptors. Br.J. Pharmacol. 176 (S1) S229 PMID: 31710718

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205Fax: (+44) 01392 279510
[email protected]

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

[email protected] 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : [email protected]


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: [email protected]


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: [email protected]


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: [email protected]


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: [email protected]

India
Biotechno Labs
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: [email protected]


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email: [email protected]


All distributors >