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Dibutyryl-cAMP, sodium salt
Cat. No. KS-280
Structure:
N6,O2′-Dibutyryl adenosine 3′,5′-cyclic monophosphate sodium salt
Other Names:
Bucladesine sodium, Dibutyryl cyclic AMP, dBcAMP
Activity:
PKA activator
Dibutyryl-cAMP sodium salt is a cell-permeable analogue of cAMP that activates protein kinase A (PKA), also known as cAMP-dependent protein kinase, and is also a phosphodiesterase inhibitor. Dibutyryl-cAMP sodium salt promotes neurite outgrowth in cell cultures, has anti-inflammatory activity and can be used to promote wound healing. In a cocktail with other agents, dibutyryl-cAMP sodium salt promotes differentiation of neural stem/progenitor cells (NSPCs) and increases survival rates and differentiation into neurons in vivo.
Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J Physiol. 511 1 235 PMID: 9679177
Kim et al (2011) Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats. PLoS One 6(6) e21744 PMID: 21738784
Li et al (2023) Single-cell brain organoid screening identifies developmental defects in autism. Nature 621(7978) 373 PMID: 37704762
Related areas
All small molecules >
All kinase modulators >
All stem cell research categories >
Technical Data
| Structure | N6,O2′-Dibutyryl adenosine 3′,5′-cyclic monophosphate sodium salt |
| CAS Number | 16980-89-5 |
| Molecular Weight | 491.37 |
| Formula | C18H23N5O8P.Na |
Solubility and Storage
| Solubility | Soluble in DMSO to 50 mg/ml) and water to 50 mg/ml. |
| Appearance | White solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 98% by HPLC, NMR conforms |
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Recent citations
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