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Abl substrate peptide
Cat. No. KS-160
Structure:
H-Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys-OH
Activity:
Substrate for Abl kinase
Abl substrate peptide is a synthetic peptide which can be used as a substrate for Abl kinase in kinase assays. Abl substrate peptide is phosphorylated by Abl kinase with a Km of 4 µM. Abl (Abelson) kinase is a plasma membrane associated non-receptor tyrosine kinase with transforming activity. The three lysines on the carboxy terminus of Abl substrate peptide allow it to be used in phosphocellulose kinase assays.
Songyang et al (1995) Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature 373 536 PMID: 7845468
Shore et al (2002) Transforming pathways activated by the v-Abl yrosine kinase. Oncogene 21 8568 PMID: 12476303
Related areas
Technical Data
| Structure | H-Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys-OH |
| Molecular Weight | 1336.6 |
| Formula | C64H10N15O16 |
| Sequence | EAIYAAPFAKKK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Certificate of Analysis | KS-160-1MG Abl Substrate Peptide_678681fcba7de.pdf |
| Safety Data Sheet | Abletide, Abl Kinase Substrate MSDS_613a33f8e2d54.docx |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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