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pFYN peptide
Cat. No. BT-010
Structure:
Biotin-Gly-Leu-Ala-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr(H2PO3)-Thr-Ala-Arg-Gln-Gly-Ala-Lys-Phe-Pro-Ile-OH
Activity:
Phosphorylated peptide substrate derived from FYN, a Src family kinase
pFYN peptide is a phosphorylated peptide substrate derived from FYN, a member of the Src family of kinases. pFyn peptide can be used in an AlphaLISA assay for the the identification and optimization of allosteric STEP (striatal-enriched protein tyrosine phosphatase) ligands. STEP is a critical regulator of glutamatergic synapse function and neuronal survival, acting on targets directly involved in regulation of synaptic plasticity such as the NMDA and AMPA receptors, as well as targets regulating these receptors, such as ERK1/2, p38, FYN, and PYK2. pFYN-peptide phosphorylated peptide substrate is used in place of the endogenous STEP substrate FYN.
Tautermann et al (2019) Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. J.Med.Chem. 62 306 PMID: 30207464
Related areas
All biotin labelled peptides >
All substrate peptides >
All kinase modulators >
Technical Data
| Structure | Biotin-Gly-Leu-Ala-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr(H2PO3)-Thr-Ala-Arg-Gln-Gly-Ala-Lys-Phe-Pro-Ile-OH |
| Molecular Weight | 2764.95 |
| Formula | C115H183N32O43PS |
| Sequence | GLARLIEDNEYTARQGAKFPI |
| Modifications | Biotin at N terminal glycine, tyrosine 11 is phosphorylated |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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