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Appetite regulation

Obesity is a metabolic condition which results from a combination of low energy expenditure and high caloric intake although numerous susceptibility genes have been identified.  Appetite control originates from the hypothalamus where an appetite stimulatory and an appetite inhibitory circuit oppose each other, influenced by peripheral hormones that provide feedback on energy intake and expenditure.  Uncontrolled obesity in humans increases the risk of other diseases, the most common being type 2 diabetes and a variety of cardiovascular complications including hypertension, coronary artery disease and stroke.

Further reading

Druce and Bloom (2006) The regulation of appetite. Arch. Dis Child. 91(2) 183 PMID: 16428368

Suzuki et al (2011) The Gut Hormones in Appetite Regulation. J. Obesity 2011 Article ID 528401 PMID: 21949903

Perry and Wang (2012) Appetite regulation and weight control: the role of gut hormones. Nutr. Diabetes 2 e26 PMID: 23154682


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