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Phospho glycogen synthase peptide 2 

Cat. No. SP-030

Structure:

H-Tyr-Arg-Arg-Ala-Ala-Val-Pro-Pro-Ser-Pro-Ser-Leu-Ser-Arg-His-Ser-Ser-Pro-His-Gln-Ser(OPO3H2)-Glu-Asp-Glu-Glu-Glu-OH

Other Names:

GS peptide 2

Activity:

Glycogen synthase kinase 3 (GSK 3) substrate 
Price Qty
1 mg    £ 155.00

Phospho glycogen synthase peptide 2 is a synthetic peptide substrate for glycogen synthase kinase 3 (GSK 3).  Phospho glycogen synthase peptide 2 when immobolised can be used for affinity purification of protein-serine kinases.  Phospho glycogen synthase peptide 2 can also be used to inhibit the human dual specificity protein kinase CLK2.

Woodgett (1989) Use of peptide substrates for affinity purification of protein-serine kinases. Anal.Biochem. 180 237 PMID: 2554753

Sutherland et al (1993) Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in Ins and growth factor signalling. Biochem.J. 296 15 PMID: 8250835

Tanji et al (2002) A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J Biol Chem. 277(40):36955 PMID: 12147701


Related areas

Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate
All kinase modulators >
All substrate peptides >


Technical Data

Structure H-Tyr-Arg-Arg-Ala-Ala-Val-Pro-Pro-Ser-Pro-Ser-Leu-Ser-Arg-His-Ser-Ser-Pro-His-Gln-Ser(OPO3H2)-Glu-Asp-Glu-Glu-Glu-OH
CAS Number 851366-97-7
Molecular Weight 3029
Formula C123H191N40O48P
Sequence YRRAAVPPSPSLSRHSSPHQS(P)EDEEE
Modifications Ser-21 is phosphorylated

Solubility and Storage

Solubility Soluble to 1 mg/ml in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

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