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Phospho glycogen synthase peptide 2
Cat. No. SP-030
Structure:
Other Names:
Activity:
Phospho glycogen synthase peptide 2 is a synthetic peptide substrate for glycogen synthase kinase 3 (GSK 3). Phospho glycogen synthase peptide 2 when immobolised can be used for affinity purification of protein-serine kinases. Phospho glycogen synthase peptide 2 can also be used to inhibit the human dual specificity protein kinase CLK2.
Woodgett (1989) Use of peptide substrates for affinity purification of protein-serine kinases. Anal.Biochem. 180 237 PMID: 2554753
Sutherland et al (1993) Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in Ins and growth factor signalling. Biochem.J. 296 15 PMID: 8250835
Tanji et al (2002) A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J Biol Chem. 277(40):36955 PMID: 12147701
Related areas
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate
All kinase modulators >
All substrate peptides >
Technical Data
| Structure | H-Tyr-Arg-Arg-Ala-Ala-Val-Pro-Pro-Ser-Pro-Ser-Leu-Ser-Arg-His-Ser-Ser-Pro-His-Gln-Ser(OPO3H2)-Glu-Asp-Glu-Glu-Glu-OH |
| CAS Number | 851366-97-7 |
| Molecular Weight | 3029 |
| Formula | C123H191N40O48P |
| Sequence | YRRAAVPPSPSLSRHSSPHQS(P)EDEEE |
| Modifications | Ser-21 is phosphorylated |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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