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LRRKtide
Cat. No. KS-010
Structure:
H-Arg-Leu-Gly-Arg-Asp-Lys-Tyr-Lys-Thr-Leu-Arg-Gln-Ile-Arg-Gln-OH
Activity:
Leucine rich repeat kinase 2 (LRRK2) substrate
LRRKtide is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM protein family members ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553), proteins which influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site. LRRK2 is found in most organs and is involved in several cellular pathways. The LRRK2 gene and α-synuclein gene (SNCA) are the key influencing factors of Parkinson’s disease (PD), with dysfunction of LRRK2 influencing the accumulation of α-synuclein.
Jaleel et al (2007) LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem. J. 405 (2) 307 PMID: 17447891
Anand and Braithwaite (2009) LRRK2 in Parkinson’s disease: biochemical functions. FEBS J. 276 6428 doi:10.1111/j.1742-4658.2009.07341.x
Esteves et al (2014) LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis. Exp. Neurol. 261 206 PMID: 24907399
Related areas
All kinases >
All substrate peptides >
All neuroscience categories >
Technical Data
| Structure | H-Arg-Leu-Gly-Arg-Asp-Lys-Tyr-Lys-Thr-Leu-Arg-Gln-Ile-Arg-Gln-OH |
| Molecular Weight | 1931.28 |
| Formula | C83H147N31O22 |
| Sequence | RLGRDKYKTLRQIRQ |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | LRRKtide MSDS_602bf65d835c6.pdf |
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Recent citations
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