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Ubiquitin-proteasome system
The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in eukaryotes. The ubiquitin-proteasome system consists of many factors that include E3 ubiquitin ligases, ubiquitin hydrolases, ubiquitin and ubiquitin-like molecules, and the proteasome itself. The proteasomal degradation pathway is essential for many cellular processes, including the cell cycle, the regulation of gene expression, and responses to oxidative stress.
Ubiquitin-proteasome system categories
Further reading
Muratani and Tansey (2003) How the ubiquitin–proteasome system controls transcription. Nat. Rev. Mol Cell Biol. 4 192 PMID: 12612638
Lecker et al (2006) Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States. JASN 7(7) 1807 PMID: 16738015
Gong et al (2016) The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury. Front. Molecular Neurosci. 9 4 PMID: 26858599
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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