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Diabetes

Diabetes mellitus (diabetes), is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time.  Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced.  There are two major types of diabetes mellitus, type 1 diabetes results from the pancreas's failure to produce enough insulin due to loss of beta cells, in turn caused by an autoimmune response.  In type 2 diabetes cells fail to respond to insulin.  The most common cause is a combination of excessive body weight and insufficient exercise.

Further reading

Rother (2007) Diabetes treatment-bridging the divide. N. Engl.J. Med. 356(15) 1499 PMID: 17429082

Litwinoff et al (2015) Emerging Targets for Therapeutic Development in Diabetes and Its Complications: The RAGE Signaling Pathway. Clin Pharmacol Ther. 98(2)135 PMID: 25974754

Satin et al (2021) New Aspects of Diabetes Research and Therapeutic Development. Pharmacol Rev. 73(3) PMID: 34193595


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