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RS repeat peptide

Cat. No. SP-040

Structure:

H-Gly-Arg-Ser-Arg-Ser-Arg-Ser-Arg-Ser-Arg-Ser-Arg-Ser-Arg-Ser-Arg-OH

Activity:

Dual specificity protein kinase CLK1 substrate
Price Qty
1 mg    $ 75.00
RS repeat peptide is a peptide substrate for the dual specificity protein kinase CLK1. RS repeat peptide can also be used as a substrate in assays for eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK) and serine/arginine rich protein specific kinase (SRPK).

Schmitt et al (2014) Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors. Plos One 9(3) e87851 PMID: 24676346

Darwish et al (2018) Development of novel amide–derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification. Eur. J. Med. Chem. 158 270 PMID: 30223116


Related areas

All kinase modulators >
All substrate peptides >


Technical Data

Structure H-Gly-Arg-Ser-Arg-Ser-Arg-Ser-Arg-Ser-Arg-Ser-Arg-Ser-Arg-Ser-Arg-OH
Molecular Weight 1934.11
Formula C71H126N40O24
Sequence GRSRSRSRSRSRSRSR
Modifications None

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC

Contact Information

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Italy
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BIOHUB INTERNATIONAL 

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