Endonucleases

Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain. Some, such as deoxyribonuclease I, cut DNA relatively nonspecifically, others, typically called restriction endonucleases or restriction enzymes, cleave only at very specific nucleotide sequences. Endonucleases differ from exonucleases, which cleave the ends of recognition sequences instead of the middle (endo) portion.

Further reading

Pingoud and Jeltsch (2001) Structure and function of type II restriction endonucleases. Nucleic Acids Res. 29 (18) 3705 PMID: 11557805

Marzec and Hensel (2019), More precise, more universal and more specific – the next generation of RNA‐guided endonucleases for genome editing. FEBS J 286 4657 PMID: 31612609

Lutz et al (2019) A protein architecture guided screen for modification dependent restriction endonucleases. Nucleic Acids Res. 47(18) 9761 PMID: 31504772

Related Targets

Dehydrogenases GTPases Kinases

Proteases Protein-sorting transpeptidase Transferases

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Pharmacology

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Pharmacology

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Endonucleases

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