Regulated cell death

Regulated cell death is a process in organisms that is essential for tissue homeostasis or to restore equilibrium following stress.  Unlike acccidental cell death, regulated cell death involves tightly ordered signalling cascades and well defined effector mechanisms.  Multiple cell death pathways have been defined including apoptosis, autophagy, necrosis, necroptosis, pyroptosis, ferroptosis, entotic cell death, lysosome-dependent cell death, alkaliptosis, oxeiptosis, and netotic cell death. The loss of control of regulated cell death contributes to neurodegeneration, autoimmune and infectious diseases, and cancer.

Further reading

Tang et al (2019) The molecular machinery of regulated cell death. Cell. Res. 29 347 PMID: 30948788

De Re et al (2019) Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease. Physiological Rev. 99(4) 1765 PMID: 31364924

Flores-Romero et al (2020) A lipid perspective on regulated cell death. International Rev. Cell Molecular Biol. 351 197 PMID: 32247580

Shen et al (2023) Different types of cell death and their shift in shaping disease. Cell Death Discov. 9 284 https://doi.org/10.1038/s41420-023-01581-0