Search
0
Items
Select
Search
MENU
Select

Ion channel modulators

Ion channels are pore-forming membrane proteins which allow the passage of ions in and out of a cell through the plasma membrane, with hundreds of different types of ion channel being identified in the membranes of all biological cells.  Ion channels can be classified by different properties, including by the gating mechanism or the ion selectivity of the pore.  Ion channels classified by gating mechanism include voltage-gated ion channels, ligand-gated ion channels, light-gated ion channels, mechanosensitive ion channels, cyclic nucleotide-gated ion channels, calcium-gated ion channels and ions classified by ion selectivity include calcium, potassium, sodium, chloride, protons and non-selective.  Ion channels are essential for life and play a fundamental role in physiological processes such as muscle contraction and nutrient transport.  A multitude of diseases result from the disruption of normal ion channel function. 

Further reading

Camerino et al (2007) Ion channel pharmacology. Neurotherapeutics 4 184 PMID: 17395128

Alexander et al (2011) Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol. 64 Suppl 1(Suppl 1):S1 PMID: 22040146

Kadir et al (2018) Emerging Roles of the Membrane Potential: Action Beyond the Action Potential. Front Physiol. 9 1661 PMID: 30519193



Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

sales@focusbiomolecules.com 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


All distributors >