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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
Kemptide
Cat. No. KS-030
Structure:
H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH
Activity:
cAMP-dependent protein kinase (PKA) substrate
Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA). Kemptide is derived from a phosphorylation sequence of pig liver pyruvate kinase, a natural PKA substrate and is a phosphate acceptor peptide that when used as a synthetic substrate for PKA has a Km of 16 µM. Kemptide has kinetics comparable to native protein substrates.
Giembycz and Diamond (1990) Evaluation of Kemptide, a synthetic serine containing heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in respiratory tissues Biochem. Pharmacol. 39(2) 271 PMID: 2154228
Galello et al (2010) Characterization of substrates that have a differential effect on Saccharomyces cerevisiae protein kinase A holoenzyme activation. J. Biol. Chem. 285(39) 29770 PMID: 20639203
Mena-Ulecia et al (2014) Study of the Affinity between the Protein Kinase PKA and Peptide Substrates Derived from Kemptide Using Molecular Dynamics Simulations and MM/GBSA. PLoS ONE 9(10) e109639 PMID: 25275314
Related areas
Technical Data
| Structure | H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH |
| CAS Number | 65189-71-1 |
| Molecular Weight | 771.9 |
| Formula | C32H61N13O9 |
| Sequence | LRRASLG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Kemptide MSDS_602be38e6f8e9.pdf |
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Recent citations
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