Search
0
Items
Select
Search
MENU
Select

7-Transmembrane receptors

7-Transmembrane receptors (7-TM receptors), also known as G protein-coupled receptors, or GPCRs, are integral membrane proteins that contain seven membrane-spanning helices.  Many endogenous peptides activate G protein-coupled receptors.

GPCRs constitute the largest and most diverse protein family in the human genome with over 800 members identified to date.  They play critical roles in numerous cellular and physiological processes, including cell proliferation, differentiation, neurotransmission, development and apoptosis.  Aberrant receptor activity has been demonstrated in numerous disorders, and as a result GPCRs have become a very successful drug target class in pharmaceuticals treating a wide variety of indications such as pain, inflammation, neurobiological and metabolic diseases.

Further reading

Gutierrez and McDonald (2018) GPCRs: Emerging anti-cancer drug targets. Cell. Signalling 41 65 PMID: 28931490

Edin Muratspahić et al (2019) Nature-Derived Peptides: A Growing Niche for GPCR Ligand Discovery, Trends in Pharmacological Sci. 40(5) 309 PMID: 30955896

Davenport et al (2020) Advances in therapeutic peptides targeting G protein-coupled receptors. Nat. Rev. Drug Discov. 19 389 PMID: 32494050




Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205Fax: (+44) 01392 279510
[email protected]

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

[email protected] 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : [email protected]


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: [email protected]


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: [email protected]


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: [email protected]


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: [email protected]

India
Biotechno Labs
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: [email protected]


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email: [email protected]


All distributors >