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PKA inhibitor (6-22) amide
Cat. No. KS-060
Structure:
H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
Other Names:
PKI(6-22) amide
Activity:
cAMP-dependent protein kinase (PKA) inhibitor
PKA inhibitor (6-22) amide, also known as PKI(6-22) amide, is an inhibitor of cAMP-dependent protein kinase (PKA). PKA Inhibitor (6-22) amide is derived from the active section of the heat-stable PKA inhibitor PKI, the endogenous PKA inhibitor protein, and is the shortest synthetic PKI peptide with high potency for PKA inhibition. PKA inhibitor (6-22) amide inhibition of PKA can decrease long-term potentiation (LTP) at hippocampal synapses and reverse morphine tolerance.
Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem. 264 8802 PMID: 2722799
Glass et al (1989) Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. J.Biol.Chem. 264 14579 PMID: 2760075
Otmakhova et al (2000) Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J.Neurosci. 20 4446 PMID: 10844013
Related data
All peptides >
All kinase modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 |
| CAS Number | 121932-06-7 |
| Molecular Weight | 1868.1 |
| Formula | C80H130N28O24 |
| Sequence | TYADFIASGRTGRRNAI-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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