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Rad17 derived peptide
Cat. No. SP-050
Structure:
H-Ala-Ser-Glu-Leu-Pro-Ala-Ser-Gln-Pro-Gln-Pro-Phe-Ser-Ala-Lys-Lys-Lys-OH
Activity:
ATR kinase substrate
Rad17 derived peptide is an ATR (ATM and Rad-3) related kinase substrate. ATR is a serine/threonine-specific protein kinase that along with ATM (ataxia telangiectasia mutated) is involved in sensing DNA damage and activating the DNA damage checkpoint, leading to cell cycle arrest. ATR inhibition sensitises cancer cells to DNA damaging agents, making it an attractive target for cancer therapy. Rad17 derived peptide is an effective substrate in ATR kinase assays and has been used succesfully to identify novel ATR kinase inhibitors.
ChEMBL Assay Report Card ID: CHEMBL3705961
Kim et al (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem. 274(53) 37538 PMID: 10608806
Charrier et al (2011) Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 54(7) 2320 PMID: 21413798
Kawasumi et al (2014) Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. Cancer Res. 74(24) 7534 PMID: 25336189
Related areas
All kinase modulators >
All substrate peptides >
All cancer research categories >
Technical Data
| Structure | H-Ala-Ser-Glu-Leu-Pro-Ala-Ser-Gln-Pro-Gln-Pro-Phe-Ser-Ala-Lys-Lys-Lys-OH |
| Molecular Weight | 1814.07 |
| Formula | C81H132N22O25 |
| Sequence | ASELPASQPQPFSAKKK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Certificate of Analysis | SP-050-1MG Rad17 derived peptide 0850-C0124 C of A_66796111114f6.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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