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Antivirals

Viruses cause familiar infectious diseases such as influenza, rubella and warts. Multiple virus families exist and cause severe illnesses such as HIV/AIDS, hepatitis B and C and ebola. Viral diseases are a major health concern, with many people chronically infected. Some cancers are caused by viruses. Antivirals are agents with the ability to either prevent viral infections or inhibit virus replication. As virus replication depends on host-cell machinery, many antiviral agents act on the key proteins involved in this process although antiviral drugs also target viral entry and modulation of the cellular defence system. Some antivirals target components of the host cell and alter the ability of the virus to replicate efficiently, while others bind to the viral polymerase complex and restrict viral replication. RNA polymerase is essential for the replication of numerous RNA viruses Mechanisms of antiviral action include entry inhibitors of transcription, viral ribonuclease H, HBV surface antigen secretion, viral protease, RNA-dependent RNA polymerase, reverse transcriptase, viral neuraminidase, integrase strand transfer, DNA polymerase inhibitor and modulators of viral capsid assembly.

Antivirals categories

Further reading

Paintsil and Cheng (2009) Antiviral Agents. Encyclopedia of Microbiology 223 PMC7149689

De Clercq and Li (2016) Approved Antiviral Drugs over the Past 50 Years Clinical Microbiology Reviews 29(3) 695 PMID: 27281742

Andersen et al (2020) Discovery and development of safe-in-man broad-spectrum antiviral agents. Int. J. Infectious Diseases 93 268 PMID: 32081774

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

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Tel: (+44) 01392 422205Fax: (+44) 01392 279510
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CliniSciences
Tel : +33 9 77 40 09 09
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Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
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Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
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Spain and Portugal
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Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
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China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: [email protected]

India
Biotechno Labs
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: [email protected]


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email: [email protected]


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