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Glucagon and related receptors

Glucagon and related peptide receptors are a group of G-protein-coupled receptors that are currently classified into six subtypes; glucagon, glucagon-like peptide 1 (GLP-1), GLP-2, secretin, growth hormone releasing hormone (GHRH) and gastric inhibitory peptide (GIP).  This family of class II G-protein-coupled receptors serve multiple biological functions including the regulation of nutrient homeostasis through effects on islet hormone secretion, gastrointestinal motility and cell proliferation.
Peptides
Cat No. Product Name Activity
GH-001 Exendin-4 Glucagon like peptide 1 (GLP-1) receptor agonist
GH-008 Exendin-4 (3-39) amide Glucagon like peptide 1 (GLP-1) receptor antagonist
GH-009 Exendin-4 (5-39) amide Glucagon like peptide 1 (GLP-1) receptor antagonist
GH-010 Exendin-4 (9-39) amide Glucagon like peptide-1 (GLP-1) receptor antagonist
GH-160 GIP (1-39) Endogenous truncated form of GIP 
GH-150 GIP (human) Stimulates insulin release
GL-020 GIP (porcine)  Stimulates insulin secretion
GH-170 GIP-1 (3-42) (human) Competes with GIP for the receptor binding site
GL-040 GIP_HUMAN[22–51] Endogenous proatherosclerotic peptide hormone
GH-030 GLP-1 (1-36) amide Proglucagon (72-107) proteolysis product
GH-020 GLP-1 (1-37) (human, rat) Pancreatic hormone from posttranslational proglucagon proteolysis
GH-050 GLP-1 (7-36) amide (human, rat) Insulinotropic incretin peptide hormone
GL-030 GLP-1 (7-37) Endogenous GLP-1 receptor agonist
GH-040 GLP-1 (9-36) amide Major metabolite of glucagon like peptide GLP-1 (7-36) amide
GL-010 Glucagon (1-29) Endogenous glucagon receptor agonist
GH-070 Oxyntomodulin Endogenous glucagon like peptide receptor agonist

Further reading

Brubaker and Drucker (2002) Structure-function of the glucagon receptor family of G protein-coupled recptors; the glucagon, GIP, GLP-1, and GLP-2 receptors. Receptors Channels 8 179 PMID: 12529935

Mayo et al (2003) International union of pharmacology. XXXV. The glucagon receptor family. Pharmacol.Rev. 55 167 PMID: 12615957

Finan et al (2020) Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes. 69(4) 532 PMID: 31178432

Zheng et al (2024) Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Signal Transduct Target Ther. 9(1) 234 PMID: 39289339

De Giorgi et al (2025) An analysis on the role of glucagon-like peptide-1 receptor agonists in cognitive and mental health disorders. Nat. Mental Health https://doi.org/10.1038/s44220-025-00390-x

Karacabeyli and Lacaille (2025) Glucagon-like peptide-1 receptor agonists in arthritis: current insights and future directions. Nat Rev Rheumatol. https://doi.org/10.1038/s41584-025-01302-0


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