Tachykinin receptors

Tachykinin peptides constitute one of the largest peptide families with more than 40 tachykinins identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B.  Three main tachykinin receptor subtypes have been characterised, NK1, NK2 and NK3.  Tachykinins are involved in multiple diseases processes including acute and chronic inflammation and pain, fibrosis, affective and addictive disorders, disorders of the intestine and bladder, infection and cancer.

Further reading

Ramalho et al (2011) Tachykinin receptors antagonism for asthma: a systematic review. BMC Pulm. Med. 11 41 PMID: 21810226

Steinhoff et al (2014)  Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol. Rev. 94(1) 265  PMID: 24382888

Nässel et al (2019) Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic.  Front. Neurosci.13 1262 PMID: 31824255

Thor and Prömel (2025) Beyond incretins: targeting neurokinin receptors for obesity treatment. Sig Transduct Target Ther 10 21 https://doi.org/10.1038/s41392-024-02100-y