Corticotropin releasing factor receptors

Corticotropin releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioural and neuroendocrine responses to stress. Two subtypes of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors, and two splice variants of the CRF2 receptor have been identified in rodents, CRF2a and CRF2b. CRF has also been suggested to play a role in cell growth and survival.

Peptides

Cat No.	Product Name	Activity
CR-020	CRF (human, rat)	Endogenous CRF receptor agonist
CR-010	α-helical CRF (9-41)	CRF antagonist

Further reading

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312 PMID: 10816663

Maciejewski-Lenoir et al (200) Selective impairment of corticotropin-releasing factor1 (CRF1) receptor-mediated function using CRF coupled to saporin. Endocrinology 141 498 PMID: 10650928

Slater et al (2016) Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences. Mol. Pharmacol. 90(5) 627 PMID: 27612874

Related Targets

Peptide receptors

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Pharmacology

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Pharmacology

Type

Research Area

Pharmacology

Type

Research Area

Corticotropin releasing factor receptors

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