Apelin receptors

The apelin receptor (AR or APJ) is a class A (rhodopsin-like) G-protein coupled receptor (GPCR) with wide distribution throughout the human body.  Activation of the apelin receptor by its cognate peptide ligand apelin induces diverse physiological effects including vasoconstriction and dilation, strengthening of heart muscle contractility, angiogenesis, regulation of energy metabolism, fluid homeostasis and adipocyte endocrine secretion.

Further reading

Chapman et al (2014) The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR. Biochem Cell Biol. 92(6) 431 PMID: 25275559

Zhang et al (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Front. Endocrinol. 9 756 PMID: 30631305

Tian (2020) The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target. Front. Neurol. 11 75 PMID: 32194492