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GLP-1 (9-36) amide

Cat. No. GH-040

Structure:

H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Other Names:

Glucagon-like peptide-1 (9-36) amide

Activity:

Major metabolite of glucagon like peptide GLP-1 (7-36) amide
Price Qty
1 mg    £ 145.00
GLP-1 (9-36) amide, or Glucagon-like peptide-1 (9-36) amide, is a glucoregulatory peptide and the human N-terminally truncated major metabolite of glucagon-like peptide GLP-1 (7-36) amide, formed by dipeptidyl peptidase-IV (DPP IV) cleavage. GLP-1 (9-36) amide acts as an antagonist at the human GLP-1 receptor, inhibits hepatic glucose production and is a weak insulinotropic agent.

Knudsen and Pridal (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur. J. Pharmacol. 318(2-3) 429 PMID: 9016935

Elahi et al (2008) GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity 16(7) 1501 PMID: 18421270

Sathananthan et al (2013) Direct Effects of Exendin-(9,39) and GLP-1-(9,36)amide on Insulin Action, β-Cell Function, and Glucose Metabolism in Nondiabetic Subjects. Diabetes 62(8) 2752 PMID: 23545708


Related areas

All peptides >
All glucagon and related receptor modulators >
All endocrinology research categories >
All diabetes research categories >


Technical Data

Structure H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
CAS Number 161748-29-4
Molecular Weight 3089.4
Formula C140H214N36O43
Sequence EGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Modifications C terminal amide

Solubility and Storage

Solubility Soluble in dilute acid
Appearance Freeze dried solid
Storage Store dry, frozen and desiccated

Batch Specific Data

Purity >95% by HPLC

Contact Information

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