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7-Transmembrane receptors
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Glucagon and related receptors
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GLP-1 (7-36) amide (human, rat)
GLP-1 (7-36) amide (human, rat)
Cat. No. GH-050
Structure:
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Activity:
Insulinotropic incretin peptide hormone
GLP-1 (7-36) amide is a potent insulinotropic incretin peptide hormone produced as a result of proteolytic post-translational modification of proglucagon in L-cells of the lower intestine. GLP-1 (7-36) amide displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells with a Kd of 204 pM. GLP-1 (7-36) amide stimulates insulin gene transcription and secretion in pancreatic β-cells, displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.
Perfetti and Merkel (2000) Glucagon-like peptide-1: a major regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717 PMID: 11124853
Perry et al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881 PMID: 12183643
Marchetti et al (2012) A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets. Diabetologia 55(12) 3262 PMID: 22965295
Related areas
All peptides >
All glucagon and related receptor modulators >
All endocrinology research categories >
All diabetes research categories >
Technical Data
| Structure | H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 |
| CAS Number | 107444-51-9 |
| Molecular Weight | 3297.7 |
| Formula | C149H226N40O45 |
| Sequence | HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
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