Cholecystokinin receptors

Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin. The CCK1 receptor has a high affinity for sulphated CCK analogues, whereas the CCK2 receptor has similar affinity for sulphated and non-sulphated forms.

Peptides

Cat No.	Product Name	Activity
CC-010	Gastrin I (human)	Endogenous CCK2 receptor agonist.

Further reading

Wank (1995) Cholecystokinin receptors. Am J Physiol. 269(5 Pt 1):G628 PMID: 7491953

Dufresne (2006) Cholecystokinin and Gastrin Receptors. Physiological Reviews 86(3) 805 PMID: 16816139

Bowers et al (2012) Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y. Physiol Behav. 107(5) 699 PMID: 22429904

Huang et al (2005) Cholecystokinin facilitates the formation of long-term heterosynaptic plasticity in the distal subiculum. Commun Biol 8 153 https://doi.org/10.1038/s42003-025-07597-9

Garcia et al (2026) Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development. Nat Commun. https://doi.org/10.1038/s41467-026-69821-2

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Cholecystokinin receptors

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