PACAP receptors

PACAP (Pituitary adenylate cyclase-activating polypeptide) receptors are Gs-protein-coupled receptors referred to as PAC1, with an endogenous ligand, PACAP, that also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the central nervous system, including the olfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum as well as in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock, emotional control of behaviour, anxiolysis and control of adrenal medulla catecholamine release.

Peptides

Cat No.	Product Name	Activity
PA-030	PACAP (6-38)	PAC1 receptor antagonist
PA-010	PACAP 27	Endogenous PAC1 receptor agonist
PA-020	PACAP 38	Endogenous PAC1 receptor agonist

Further reading

Erdling et al (2013) VIP/PACAP receptors in cerebral arteries of rat: characterization, localization and relation to intracellular calcium. Neuropeptides 47(2) 85 PMID: 23375386

Hirabayashi et al (2018) Discovery of PACAP and its receptors in the brain. J Headache Pain 19 28 PMID: 29619773

Farnham et al (2019) PACAP-PAC1 Receptor Activation Is Necessary for the Sympathetic Response to Acute Intermittent Hypoxia. Fronti. Neuroscience 13 881 PMID: 31496933

Related Targets

Peptide receptors

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Pharmacology

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Pharmacology

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Pharmacology

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PACAP receptors

Peptides

Related Targets

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