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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Neuropeptide Y receptors
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes, Y1, Y2, Y4 and Y5. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. Neuropeptide Y receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release.
Peptides
| Cat No. | Product Name | Activity |
|---|---|---|
| GH-060 | Neuropeptide Y (human, rat) | Endogenous neuropeptide Y receptor agonist |
| GH-210 | Neuropeptide Y (porcine) | Endogenous neuropeptide Y agonist |
| NY-030 | Pancreatic polypeptide (human) | Endogenous agonist for the human NPY Y4 receptor |
| GH-120 | Peptide YY (3-36) (human) | Neuropeptide Y2 receptor agonist |
| GH-110 | Peptide YY (human) | Neuropeptide Y agonist that binds all subtypes with similar affinity |
| NY-010 | [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic polypeptide | Potent and selective Y5 agonist |
| NY-020 | [Leu31,Pro34]-Neuropeptide Y (human, rat) | Selective neuropeptide Y Y1 receptor agonist |
Further reading
Brothers and Wahlestedt (2010) Therapeutic potential of neuropeptide Y (NPY) receptor ligands. EMBO Mol. Med. 2(11) 429 PMID: 20972986
Pedragosa-Badia et al (2013). Neuropeptide Y receptors: how to get subtype selectivity. Front. Endocrinol. 4 5 PMID: 23382728
Li et al (2015) Neuropeptide Y receptors: a promising target for cancer imaging and therapy, Regen. Biomat. 2(3) 215 PMID: 26816643
Related Targets
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