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7-Transmembrane receptors
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Glucagon and related receptors
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GLP-1 (1-36) amide
GLP-1 (1-36) amide
Cat. No. GH-030
Structure:
H-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Activity:
Proglucagon (72-107) proteolysis product
GLP-1 (1-36) amide is the posttranslational product of proteolysis of proglucagon (72-107)
Schmidtler et al (1991) GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function. Am. J. Phys. Gast. Liver Physiol. 260(6) G940 PMID: 1711782
Koole et al (2013) Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochem. Soc. Trans. 41(1) 172 PMID: 23356279
Related areas
All peptides >
All glucagon and related receptor modulators >
All endocrinology research categories >
Technical Data
| Structure | H-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 |
| CAS Number | 99658-04-5 |
| Molecular Weight | 4111.5 |
| Formula | C184H273N51O57 |
| Sequence | HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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