GLP-1 (1-37) (human, rat)

Cat. No. GH-020

Structure:

H-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH

Other Names:

GLP-1 (1-37)

Activity:

Pancreatic hormone from posttranslational proglucagon proteolysis

Price	Qty
1 mg £ 225.00

GLP-1 (1-37) is a pancreatic hormone resulting from post-translational proteolysis of proglucagon. GLP-1(1-37) does not affect food intake in rats and does not enhance pancreatic insulin. It is secreted by the small intestine in response to nutrient ingestion with wide-ranging effects on glucose metabolism, including stimulation of insulin release, inhibition of glucagon secretion, reduction of gastric emptying and satiety. The insulinotropic actions of GLP-1 depend on ambient glucose concentrations, making it highly relevant in type 2 diabetes. GLP-1 (1-37) also has an important role in the cardiovascular system.

Suzuki et al (2003) Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into Ins-producing cells. Proc.Natl.Acad.Sci.USA 100 5034 PMID: 12702762

Grieve et al (2009) Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control? Br. J. Pharmacol. 157(8) 1340 PMID: 19681866

Zhao et al (2012) Glucagon-like peptide-1(1–37) can enhance blood glucose homeostasis in mice. Reg. Pept. 178(1-3) 1 PMID: 22749990

Technical Data

Structure	H-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH
CAS Number	87805-34-3
Molecular Weight	4169.5
Formula	C186H275N51O59
Sequence	HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Modifications	None

Solubility and Storage

Solubility	Soluble in dilute acid
Appearance	Freeze dried solid
Storage	Store dry, frozen and desiccated

Batch Specific Data

Purity

>95% by HPLC

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GLP-1 (1-37) (human, rat)

Cat. No. GH-020

Structure:

Other Names:

Activity:

Technical Data

Solubility and Storage

Batch Specific Data

Contact Information

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