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Products
Pharmacology
Type
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- Technical support
- Resources
Kisspeptin receptors
The kisspeptin receptor (also known as the KISS1 receptor) is a Gq/G11-protein-coupled receptor that signals through stimulation of phospholipase C resulting in Ca2+ mobilization. Kisspeptin receptors are found at high concentrations in the pancreas, placenta and brain and there are lower expression levels in the small intestine, kidney, lung, liver and heart. The kisspeptin receptor plays a key role in the neuroendocrine control of the gonadotrophin axis and has been implicated in the inhibition of metastasis.
Peptides
| Cat No. | Product Name | Activity |
|---|---|---|
| NR-070 | Kisspeptin (zebrafish) | Zebrafish neuropeptide |
| NR-050 | Kisspeptin 10 (human) | Endogenous peptide for the kisspeptin receptor KISS1 (GPR54) |
| NR-060 | Kisspeptin 10 (rat, mouse) | Endogenous peptide for the rodent kisspeptin receptor KISS1 (GPR54) |
| KR-010 | Kisspeptin 234 | Kisspeptin receptor antagonist |
Further reading
Oakley et al (2009) Kisspeptin Signaling in the Brain, Endocrine Rev. 30(6) 713 PMID: 19770291
Tng (2015) Kisspeptin signalling and its roles in humans. Singapore Med J. 56(12) 649 PMID: 26702158
Franssen and Tena-Sempere (2018) The kisspeptin receptor: A key G-protein-coupled receptor in the control of the reproductive axis. Best Pract. Res. Clin. Endocrinol. Metab. 232(2) 107 PMID: 29678280
Shah et al (2025) Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer. Sci Rep 15 35182 https://doi.org/10.1038/s41598-025-19140-1
Related Targets
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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