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Products
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Type
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- Technical support
- Resources
Mas-related G protein-coupled receptors
Mas-related G protein-coupled receptors (MRGPRs) are a family of orphan GPCRs, subdivided into nine separate subfamilies (A-H and X). They are found in mammalian species, with families A, B, C and H present only in rodents, the X subfamily only in primates, including humans, and families D to G conserved across mammalian species. The MRGPRX family consists of four distinct receptors (MRGPRX1-4) with enriched expression in mast cells and sensory neurons of the dorsal root and trigeminal ganglia. Mas-related G protein-coupled receptors are important in pain, temperature sensation and itch.
Peptides
| Cat No. | Product Name | Activity |
|---|---|---|
| PN-100 | BAM (8-22) | Potent agonist of sensory neuron specific receptors |
| PN-110 | BAM 22P | Endogenous MRGPRX1 agonist |
| SS-020 | Cortistatin 14 | Endogenous somatostatin like neuropeptide |
| MG-010 | PAMP 12 (human, porcine) | Endogenous MRGPRX2 agonist |
| MG-020 | PAMP 20 (human) | Endogenous MRGPRX2 agonist |
Further reading
Solinski et al (2014) Pharmacology and Signaling of MAS-Related G Protein–Coupled Receptors. Pharm. Rev. 66(3) 570 PMID: 24867890
Bader et al (2014) Mas and Its Related G Protein–Coupled Receptors, Mrgprs. Pharm. Rev. 66(4) 1080 PMID: 25244929
Li et al (2017) Targeting human MRGPRX1 to inhibit persistent pain. Proc. Natl. Acad. Sci 114(10) PMID: 28223516
Related Targets
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Recent citations
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