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7-Transmembrane receptors
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GIP (1-39)
GIP (1-39)
Cat. No. GH-160
Structure:
H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-Arg-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Ser-Asp-Trp-Lys-His-Asn-OH
Activity:
Endogenous truncated form of GIP
GIP (1-39) is a highly potent insulinotropic peptide, it is the endogenous truncated form of the incretin hormone GIP (Glucose-dependent Insulinotropic Polypeptide, or Gastric Inhibitory Polypeptide), a 42-amino acid peptide released by the K cells of the duodenum and jejunum in response to food intake. GIP (1-39) is more potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP and loss of the incretin effect is an early characteristic of type 2 diabetes
Xie et al (2004) GIP1-39, a novel Insulinotropic peptide form and aspects on its mechanism of action. Regul.Peptides 121 107 C PMID: 15256280
Ji et al (2016) Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer’s disease. Rev. Neurosci. 27(1) 61 PMID: 26351802
Hansen et al (2016) N‐terminally and C‐terminally truncated forms of glucose‐dependent insulinotropic polypeptide are high‐affinity competitive antagonists of the human GIP receptor. Br. J. Pharmacol. 173 826 PMID: 26572091
Related areas
All peptides >
All glucagon and related receptor modulators >
All endocrinology research categories >
All diabetes research categories >
Technical Data
| Structure | H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-Arg-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Ser-Asp-Trp-Lys-His-Asn-OH |
| CAS Number | 725474-97-5 |
| Molecular Weight | 4633.2 |
| Formula | C210H316N56O61S |
| Sequence | YAEGTFISDYSIAMDKIRQQDFVNWLLAQKGKKSDWKHN |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 10 mg per ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dark, dry and frozen |
Batch Specific Data
| Purity | >95% By HPLC |
| Safety Data Sheet | GIP (1-39) MSDS_602c0541423e4.pdf |
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Recent citations
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