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Antibacterials

Bacteria are one celled organisms, which were first identified in the 1670s and quickly found to be correlated with diseases.  Antibacterial agents are a group of materials that fight against pathogenic bacteria. By killing or reducing the metabolic activity of bacteria, their pathogenic effect in biological environments is minimized.  Synthesis of new antibacterial agents is becoming increasingly important in the light of the emerging antibiotic resistance. 

Antimicrobial peptides
Cat No. Product Name Activity
AM-330 AMPR-22

Antimicrobial peptide derived from Romo1

AM-160 Bac2A Broad spectrum antimicrobial
AM-280 BING Antimicrobial peptide isolated from Japanese medaka fish
AM-240 BLP-3 Antimicrobial, targets both gram positive and gram negative bacteria
AM-030 BMAP 28 (bovine) Bovine myeloid cathelicidin with activitiy against bacteria and fungi
AM-170 CATH-2 (chicken) Host defense peptide with strong antimicrobial activities
AM-080 Cecropin A Broad spectrum insect antimicrobial
AM-081 Cecropin B Broad spectrum insect antimicrobial peptide
AM-180 Cys-LL37 The host defence peptide LL 37 with an additional N-terminal cysteine
AM-230 Cys-Pexiganan The broad-spectrum antibacterial pexiganan with an additional N-terminal cysteine
AM-370 D-K6L9 Antimicrobial and anticancer peptide
AM-420 Epinecidin-1 Antimicrobial peptide from orange-spotted grouper
AM-380 Hc-CATH

Cathelicidin from sea snake venom

AM-090 Histatin 3 Antimicrobial peptide found in saliva
AM-091 Histatin 5 Antimicrobial peptide found in saliva
AM-092 Histatin 8 Antimicrobial peptide found in saliva
AM-320 IDR-1002 Innate defence regulator peptide
AM-070 Indolicidin Cathelicidin family antimicrobial peptide
AM-340 KLA peptide Proapoptotic mitochondrial membrane disruptor
AM-005 LL 37 (13–37) (human) Broad spectrum antimicrobial
AM-006 LL 37 (18-37) (human) Broad spectrum antimicrobial
AM-001 LL 37 (human) Host defence peptide derived from the C-terminal of human cathelicidin antimicrobial peptide
AM-002 LL 37 (human) scrambled Scrambled control peptide for LL-37
AM-100 Magainin 1 Broad spectrum antimicrobial 
AM-101 Magainin 2 Broad spectrum antimicrobial
AM-250 Mastoparan

Toxin from wasp venom

AM-260 Mastoparan X Antimicrobial isolated from wasp venom
AM-040 mCRAMP (mouse) Sole murine cathelicidin and homologue of human LL 37
AM-050 Melittin (synthetic) Haemolytic component of honey bee venom
AM-210 Melittin, C-terminal cysteine labelled Synthetic melittin with an extra cysteine residue at the C terminal
AM-360 OP-145 Antimicrobial peptide derived from LL-37
AM-290 Pap12-6 Antibacterial derived from the N-terminus of papiliocin 
AM-270 PapRIV Quorum sensing peptide from the Bacillus cereus group
AM-130 Parasin I Broad spectrum antimicrobial 
AM-310 Pexiganan Broad spectrum antibacterial agent
AM-400 PGLa Antimicrobial peptide
AM-111 PR 26 Antimicrobial
AM-110 PR 39 Cathelicidin host defence and immunomodulatory peptide
AM-151 RW2 Antimicrobial and antifungal
AM-150 RW3 Antimicrobial and antifungal
AM-152 RW4 Antimicrobial and antifungal
AM-300 SAAP 148 Antimicrobial peptide derived from LL-37
AB-020 sfTSLP (60 aa peptide) Antimicrobial, the 60 amino acid sequence of the short form of thymic stromal lymphopoietin (sfTSLP)
AB-010 sfTSLP (63 aa peptide) Antimicrobial, the 63 amino acid sequence of the short form of thymic stromal lymphopoietin (sfTSLP)
AM-020 SMAP 29 (sheep) Broad spectrum antimicrobial
AM-410 Thanatin Binds to E. Coli LptA and LptD
IM-030 Tiger17 Potent healer of skin wounds
Biotin labelled peptides
Cat No. Product Name Activity
AM-003 LL 37 (human) biotinylated N-terminally biotinylated version of the host defence peptide LL 37
AM-200 LL 37 (human) biotinylated, pegylated N-terminally biotinylated version of the host defence peptide LL 37
Cell penetrating peptides
Cat No. Product Name Activity
CP-010 Tat (48-60) Cell penetrating cationic peptide derived from the N-terminus of the Tat protein
Fluorescent labelled peptides
Cat No. Product Name Activity
AM-004 LL 37 (human), 5-FAM N-terminally carboxyfluoresceinated derivative of the host defence peptide LL 37
Peptides
Cat No. Product Name Activity
MC-010 alpha-MSH Endogenous melanocortin receptor agonist
MG-010 PAMP 12 (human, porcine) Endogenous MRGPRX2 agonist
MG-020 PAMP 20 (human) Endogenous MRGPRX2 agonist
Peptoids
Cat No. Product Name Activity
PT-100 (NaeNpheNphe)2-NH2 Antibacterial and antiparasitic
PT-101 (NaeNpheNphe)3-NH2 Antibacterial and antiparasitic
PT-090 (NaeNspeNspe)2-NH2 Antibacterial and antiparasitic
PT-091 (NaeNspeNspe)3-NH2 Antibacterial and antiparasitic
PT-092 (NaeNspeNspe)4-NH2 Antibacterial and antiparasitic
PT-106 (NahNpheNphe)2-NH2 Antibacterial and antiparasitic
PT-107 (NahNpheNphe)3-NH2 Antibacterial and antiparasitic
PT-108 (NahNpheNphe)4-NH2 Antibacterial and antiparasitic
PT-096 (NahNspeNspe)2-NH2 Antibacterial and antiparasitic
PT-097 (NahNspeNspe)3-NH2 Antibacterial and antiparasitic
PT-098 (NahNspeNspe)4-NH2 Antibacterial and antiparasitic
PT-010 (NLysNLeuNspe)3-NH2 Antibacterial and antiparasitic
PT-103 (NLysNpheNphe)2-NH2 Antibacterial and antiparasitic
PT-104 (NLysNpheNphe)3-NH2 Antibacterial and antiparasitic
PT-105 (NLysNpheNphe)4-NH2 Antibacterial and antiparasitic
PT-093 (NLysNspeNspe)2-NH2 Antibacterial and antiparasitic
PT-094 (NLysNspeNspe)3-NH2 Antibacterial and antiparasitic
PT-095 (NLysNspeNspe)4-NH2 Antibacterial and antiparasitic
Small molecules
Cat No. Product Name Activity
PI-160 Puromycin dihydrochloride Broad spectrum antibiotic

Further reading

Silver (2007) Multi-targeting by monotherapeutic antibacterials. Nat. Rev. Drug Discov. 6 41 PMID: 17159922

Fischetti (2008) Bacteriophage lysins as effective antibacterials. Current Opin. Microbiology 11(5) 393 PMID: 18824123

Gupta et al (2020) Novel Targets for Antimicrobials. Turk J Pharm Sci. 17(5) 565 PMID: 33177939

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