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Products
Pharmacology
Type
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- Technical support
- Resources
PapRIV
Cat. No. AM-270
Structure:
H-Ser-Asp-Leu-Pro-Phe-Glu-His-OH
Other Names:
PapR-IV
Activity:
Quorum sensing peptide from the Bacillus cereus group
PapRIV is a quorum sensing heptapeptide originating from the Bacillus cereus group, which comprises a number of highly related species. PapRIV possesses in vitro pro-inflammatory effects on microglial BV-2 cell lines and is able to cross the gastro-intestinal tract and the blood–brain barrier. PapRIV shows very high brain influx, suggesting a role in gut-brain signalling.
Grenha et al (2013) Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR. Proc Natl Acad Sci U S A. 110(3) 1047 PMID: 23277548
Janssens et al (2021) PapRIV, a BV-2 microglial cell activating quorum sensing peptide. Sci Rep. 11(1) 10723 PMID: 34021199
Related areas
All antimicrobial peptides >
All immunology research categories >
Technical Data
| Structure | H-Ser-Asp-Leu-Pro-Phe-Glu-His-OH |
| Molecular Weight | 843.89 |
| Formula | C38H53N9O13 |
| Sequence | SDLPFEH |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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