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Products
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- Technical support
- Resources
Hc-CATH
Cat. No. AM-380
Structure:
Other Names:
Activity:
Cathelicidin from sea snake venom
Hc-CATH is a cathelicidin from the venom of the sea snake Hydrophis cyanocinctus, unusual in being derived from a marine reptile rather than a vertebrate. Hc-CATH possesses potent broad-spectrum antimicrobial activity, acting through disruption of cell membranes and lysis of bacterial cells, while showing low cytotoxicity toward mammalian cells. Hc-CATH also exhibits potent anti-inflammatory activity, in vitro inhibiting LPS-induced production of nitric oxide and pro-inflammatory cytokines, and in vivo significantly reducing the bacterial load and inflammation in mouse models of intraperitoneal and respiratory infection. Hc-CATH confers protection against ZIKV infection and has preventative and therapeutic efficacy in pregnant mice. Hc-CATH decreases the susceptibility of host cells to ZIKV by downregulating expression of AXL, a TAM (TYRO3, AXL and MERTK) family kinase receptor that mediates ZIKV infection, and also directly inactivates ZIKV particles by disrupting the viral membrane.
Wei et al (2015) Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity and Special Mechanism. J Biol Chem. 290(27) 16633 PMID: 26013823
Carlile et al (2019) Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection. Sci Rep. 9(1) 6071 PMID: 30988402
Wang et al (2022) A cathelicidin antimicrobial peptide from Hydrophis cyanocinctus inhibits Zika virus infection by downregulating expression of a viral entry factor. J Biol Chem. 298(10) 102471 PMID: 36089062
Related areas
All antimicrobial peptides >
All antiviral agents >
All antibacterials >
Technical Data
Structure | H-Lys-Phe-Phe-Lys-Arg-Leu-Leu-Lys-Ser-Val-Arg-Arg-Ala-Val-Lys-Lys-Phe-Arg-Lys-Lys-Pro-Arg-Leu-Ile-Gly-Leu-Ser-Thr-Leu-Leu-OH |
Molecular Weight | 3626.33 |
Formula | C171H300N52O34 |
Sequence | KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL |
Modifications | None |
Solubility and Storage
Solubility | Soluble DMSO |
Appearance | Freeze dried solid |
Storage | Store dry, frozen and in the dark |
Batch Specific Data
Purity | >95% by hplc |
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Recent citations
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