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Products
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Bac2A
Cat. No. AM-160
Structure:
H-Arg-Leu-Ala-Arg-Ile-Val-Val-Ile-Arg-Val-Ala-Arg-NH2
Activity:
Broad spectrum antimicrobial
Bac2A is a 12-mer linear variant of the naturally occurring bovine host defense peptide bactenecin. Bac2A has the cysteine disulfide bond-forming residues of bactenecin replaced by alanine and is active as a broad spectrum antimicrobial activity against gram positive and gram negative bacteria, as well as against the yeast Candida albicans.
Wu and Hancock (1999) Improved Derivatives of Bactenecin, a Cyclic Dodecameric Antimicrobial Cationic Peptide. Antimicrob. Agents Chemother. 43(5) 1274 PMID: 10223951
Hilpert et al (2006) Sequence requirements and an optimization strategy for short antimicrobial peptides. Chem. Biol. 13(10) 1101 PMID: 17052614
Related areas
All antibacterials >
All antifungals >
All antimicrobial peptides >
All immunology research categories >
Technical Data
| Structure | H-Arg-Leu-Ala-Arg-Ile-Val-Val-Ile-Arg-Val-Ala-Arg-NH2 |
| Molecular Weight | 1420.8 |
| Formula | C63H120N25O12 |
| Sequence | RLARIVVIRVAR-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid. |
| Appearance | Lyophilised solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Bac2A MSDS_602ba6ba06f65.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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