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Products
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Indolicidin
Cat. No. AM-070
Structure:
H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2
Activity:
Cathelicidin family antimicrobial peptide
Indolicidin is a 13 amino acid cationic cathelicidin family anti-microbial peptide (AMP) isolated from the cytoplasmic granules of bovine neutrophils. Indolicidin exhibits membrane permeabilization effects and antimicrobial activity against a wide spectrum of pathogens which include gram-positive and gram-negative bacteria, fungi, protozoa and the HIV-1 virus. Indolicidin is also an immune system modulator and an inhibitor of aminoglycoside antibiotic resistance enzymes.
Subbalakshmi and Sitaram (1998) Mechanism of antimicrobial action of indolicidin. FEMS Microbiol. Lett. 160(1) 91 PMID: 9495018
Sitaram et al (2003) Indolicidin, a 13-residue basic antimicrobial peptide rich in tryptophan and proline, interacts with Ca(2+)-calmodulin. Biochem. Biophys. Res. Commun. 309(4) 879 PMID: 13679055
Tsai et al (2009) Coupling Molecular Dynamics Simulations with Experiments for the Rational Design of Indolicidin-Analogous Antimicrobial Peptides. J. Mol. Biol. 392(3) 837 PMID: 19576903
Nielsen and Lund R (2022) Molecular Transport and Growth of Lipid Vesicles Exposed to Antimicrobial Peptides. Langmuir 38(1) 374 PMID: 34902242
Related areas
All antimicrobial peptides >
All antifungal agents >
All antiviral agents >
All immunology research categories >
Technical Data
| Structure | H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2 |
| CAS Number | 140896-21-5 |
| Molecular Weight | 1906.3 |
| Formula | C100H132N26O13 |
| Sequence | ILPWKWPWWPWRR-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store desiccated and frozen in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Indolicidin MSDS_602be1ee88bf2.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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