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Products
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Magainin 1
Cat. No. AM-100
Structure:
H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser-OH
Activity:
Broad spectrum antimicrobial
Magainin 1 is a 23 amino acid amphipathic cationic peptide with broad-spectrum antimicrobial activities, originally extracted from the skin of the African clawed frog Xenopus laevis. Magainin 1 (and Magainin 2) are closely related hemolytic peptides which inhibit growth of bacteria by permeabilizing the cell membranes without significant toxicity against mammalian cells. The main target of magainin 1 and 2 is thought to be the lipid matrix of the membranes. Both magainin 1 and 2 are also cytotoxic to cancer cells and exhibit inhibitory action toward herpes simplex virus 1 and 2 (HSV 1 and 2)
Zasloff (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. 84(15) 5449 PMID: 3299384
Nascimento et al (2012) Evaluation of Magainin I interactions with lipid membranes: An optical and electrochemical study. Chem. Phys. Lipids 165(5) 537 PMID: 22634545
Watanabe and Kawano (2016) Channel Current Analysis for Pore-forming Properties of an Antimicrobial Peptide, Magainin 1, Using the Droplet Contact Method. Anal. Sci. 32(1) 57 PMID: 26753706
Related areas
All antimicrobial peptides >
All antiviral agents >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser-OH |
| CAS Number | 108433-99-4 |
| Molecular Weight | 2409.8 |
| Formula | C112H177N29O28S |
| Sequence | GIGKFLHSAGKFGKAFVGEIMKS |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store frozen and desiccated in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Magainin 1 MSDS_602bf6dce9fb6.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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