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Products
Pharmacology
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- Technical support
- Resources
Tiger17
Cat. No. IM-030
Structure:
H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2, disulphide bridge between cysteines 2 and 10
Activity:
Potent healer of skin wounds
Tiger17 is an 11 amino acid peptide with a disulphide bridge between cysteines 2 and 10, which is a potent healer of skin wounds. Tiger17 was designed based on the antimicrobial peptides tigerinin-RC1 and tigerinin RC2, identified from the skin secretions of the crab eating frog Fejervarya cancrivora which also exert wound healing activity. Tiger17 exerts significant effects at various stages of wound healing progresses - the induction of macrophage recruitment to the wound site at the inflammatory reaction stage, the promotion of migration and proliferation of keratinocytes and fibroblasts, and at the tissue remodeling phase. In mouse models Tiger17 accelerates the healing of full-thickness wounds and promotes re-epithelialization of skin wounds.
Tang et al (2014) A small peptide with potential ability to promote wound healing. PLoS One 9(3) e92082 PMID: 24647450
Teixeira et al (2022) Tiger 17 and pexiganan as antimicrobial and hemostatic boosters of cellulose acetate-containing poly(vinyl alcohol) electrospun mats for potential wound care purposes. Int J Biol Macromol. 209 (Pt A) 1526 PMID: 35469947
Teixeira et al (2022) Antibacterial and hemostatic capacities of cellulose nanocrystalline-reinforced poly(vinyl alcohol) electrospun mats doped with Tiger 17 and pexiganan peptides for prospective wound healing applications. Biomaterials Advances (137) 212830 https://doi.org/10.1016/j.bioadv.2022.212830
Marta et al (2024) Comparison of the adsorption of linear and cyclic antimicrobial peptides onto cellulosic compounds-reinforced poly(vinyl alcohol) films using QCM-D, Colloids and Surfaces A: Physicochemical and Engineering Aspects 687 133490 https://doi.org/10.1016/j.colsurfa.2024.133490
Related areas
All antimicrobial peptides >
All immunology research categories >
Technical Data
| Structure | H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2, disulphide bridge between cysteines 2 and 10 |
| Molecular Weight | 1377.69 |
| Formula | C62H96N20O12S2 |
| Sequence | WCKPKPKPRCH-NH2 |
| Modifications | Contains a disulphide bridge between cysteines 2 and 10 |
Solubility and Storage
| Solubility | Soluble in DMSO as stock and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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