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Products
Pharmacology
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- Technical support
- Resources
Mastoparan
Cat. No. AM-250
Structure:
H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
Activity:
Toxin from wasp venom
Mastoparan is a peptide toxin from wasp venom with antimicrobial, antiparasitic and anticancer properties. Mastoparan exerts its bactericidal activity by binding to lipid membranes, inducing pores and defects, and leaking the internal contents of vesicles and cells. Mastoparan also shows potent anticancer activity towards leukaemia, myeloma, and breast cancer cells in animal models, also through a lytic mechanism.
Longland et al (1999) The mechanism of inhibition of the Ca2+-ATPase by mastoparan. J.Biol.Chem. 274 14799 PMID: 10329678
Dos Santos Cabrera et al (2011) New Insight into the Mechanism of Action of Wasp Mastoparan Peptides: Lytic Activity and Clustering Observed with Giant Vesicles. Langmuir 27(17) 10805 PMID: 21797216
Hilchie et al (2016) Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma. Biochimica et biophysica acta. 1858(12) 3195 PMID: 27693190
Related areas
All antimicrobial peptides >
All antiparasitic agents >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2 |
| CAS Number | 72093-21-1 |
| Molecular Weight | 1479 |
| Formula | C70H131N19O15 |
| Sequence | INLKALAALAKKIL-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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