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Products
Pharmacology
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- Technical support
- Resources
D-K6L9
Cat. No. AM-370
Structure:
H-Leu-Lys-(D)Leu-Leu-Lys-(D)Lys-Leu-(D)Leu-(D)Lys-Lys-Leu-Leu-(D)Lys-Leu-Leu-NH2
Other Names:
Amp1D, Amphipathic 1D
Activity:
Antimicrobial and anticancer peptide
D-K6L9 is a host defense–like peptide composed of six lysines and nine leucines, modified by the inclusion of D-amino acids to improve antimicrobial activity and resistance to degradation by proteases. D-K6L9 shows antimicrobial and antibiofilm activities against Pseudomonas aeruginosa from cystic fibrosis patients without inducing bacterial resistance. In addition to its antimicrobial properties, in animal models D-K6L9 is able to target and arrest the growth of aggressive and hormone-resistant primary human prostate and breast tumours and prevent metastasis, effects which are correlated with increased necrosis of the tumour cells and a decrease in the tumour microvessel density. The selectivity of D-K6L9 derives from specific binding to surface phosphatidylserine and the killing of the cancer cells via cytoplasmic membrane depolarization.
Papo (2004) Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Res. 64(16) 5779 PMID: 15313920
Papo et al (2006) Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide. Cancer Res. 66(10) 5371 PMID: 16707464
Ben Hur et al (2022) Antimicrobial Peptides against Multidrug-Resistant Pseudomonas aeruginosa Biofilm from Cystic Fibrosis Patients. J Med Chem. 2022 65(13) 9050 PMID: 35759644
Related areas
All antimicrobial peptides >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | H-Leu-Lys-(D)Leu-Leu-Lys-(D)Lys-Leu-(D)Leu-(D)Lys-Lys-Leu-Leu-(D)Lys-Leu-Leu-NH2 |
| Molecular Weight | 1803.35 |
| Formula | C90H174N22O15 |
| Sequence | LKLLKKLLKKLLKLL-NH2 |
| Modifications | Leucines 3 and 8, and lysines 6,9 and 13 are D enantiomers, C terminal amide |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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