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Parasin I
Cat. No. AM-130
Structure:
H-Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser-OH
Activity:
Broad spectrum antimicrobial
Parasin I is an amphipathic antimicrobial peptide derived from the N-terminus of histone H2A of the catfish Parasilurus asotus. Parasin I has a wide antimicrobial activity and is about 12-100 times more potent than magainin 2 against a wide spectrum of microorganisms, without any hemolytic activity. In response to epidermal injury the catfish secretes parasin I into the epithelial mucosal layer, suggesting that it produces parasin I from its histone H2A by a specific protease upon injury to protect against invasion by microorganisms.
Park et al (1998) Parasin I, an antimicrobial peptide derived from histone H2A in the catfish, Parasilurus asotus. FEBS Lett. 1998 437(3) 258 PMID: 9824303
Koo et al (2008) Structure-activity relations of parasin I, a histone H2A-derived antimicrobial peptide. Peptides 29(7) 1102 PMID: 18406495
Zhao (2015) Characterization of bioactive recombinant antimicrobial peptide parasin I fused with human lysozyme expressed in the yeast Pichia pastoris system. Enzyme Microb. Technol. 77 61 PMID: 26138401
Related areas
All antimicrobial peptides >
All immunology research categories >
Technical Data
| Structure | H-Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser-OH |
| CAS Number | 219552-69-9 |
| Molecular Weight | 2000.4 |
| Formula | C82H154N34O24 |
| Sequence | KGRGKQGGKVRAKAKTRSS |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dry, dark and frozen |
Batch Specific Data
| Purity | >95% BY HPLC |
| Certificate of Analysis | AM-130-1MG Parasin-1 0222-201102_602cf219d0e18.pdf |
| Safety Data Sheet | Parasin I MSDS_602c03b7c002a.pdf |
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