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Products
Pharmacology
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- Technical support
- Resources
Melittin, C-terminal cysteine labelled
Cat. No. AM-210
Structure:
H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-Cys-NH2
Activity:
Synthetic melittin with an extra cysteine residue at the C terminal
Melittin, C-terminal cysteine labelled is synthetic melittin with an extra cysteine residue at the C terminal. Melittin is a cationic, haemolytic component of honey bee venom used to study cell and liposome lysis. Melittin is a positively charged, amphipathic 26-amino-acid peptide that associates with the phospholipids of membrane bilayers, causing cell death by forming transmembrane toroidal pores at nanomolar concentrations.
Melittin, C-terminal cysteine labelled, can be labelled with any maleimide linked tag to generate fluorescent or biotinylated derivatives.
Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811 PMID: 9663445
Shi et al (2016) Antimicrobial peptide melittin against Xanthomonas oryzae pv. oryzae, the bacterial leaf blight pathogen in rice. Appl. Microbiol. Biotechnol. 100, 5059 PMID: 26948237
Duffy et al (2020) Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer. Precis. Onc. 4 24 https://doi.org/10.1038/s41698-020-00129-0
Related areas
All antimicrobial peptides >
All kinase modulators >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-Cys-NH2 |
| Molecular Weight | 2949.63 |
| Formula | C134H234N40O32S |
| Sequence | GIGAVLKVLTTGLPALISWIKRKRQQC-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Melittin, C-terminal cysteine labelled MSDS_602bfd2a7519b.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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