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Products
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- Technical support
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CATH-2 (chicken)
Cat. No. AM-170
Structure:
H-Arg-Phe-Gly-Arg-Phe-Leu-Arg-Lys-Ile-Arg-Arg-Phe-Arg-Pro-Lys-Val-Thr-Ile-Thr-Ile-Gln-Gly-Ser-Ala-Arg-Phe-NH2
Other Names:
Chicken cathelicidin-2
Activity:
Host defense peptide with strong antimicrobial activities
CATH-2 (chicken) is one of four cathelicidins which have been identified in chickens. Cathelicidins constitute a family of host defense peptides (HDPs) and play an important role during the innate immune response and CATH-2 displays strong antimicrobial activities against many different pathogens including gram-positive and gram-negative bacteria and fungi. In addition, CATH-2 has been shown to have immunomodulatory capacities.
Cuperus et al (2013) Avian host defense peptides. Develop. Comp. Immunol. 41(3) 352 PMID: 24583933
Ordonez et al (2014) Fungicidal Mechanisms of Cathelicidins LL-37 and CATH-2 Revealed by Live-Cell Imaging. Antimicrob. Agents Chemother. 58(4) 2240 PMID: 24492359
Scheenstra et al (2019) Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action. Sci Rep 9 4780 PMID: 30886247
Related areas
All antimicrobial peptides >
All antifungal agents >
All immunology research categories >
Technical Data
| Structure | H-Arg-Phe-Gly-Arg-Phe-Leu-Arg-Lys-Ile-Arg-Arg-Phe-Arg-Pro-Lys-Val-Thr-Ile-Thr-Ile-Gln-Gly-Ser-Ala-Arg-Phe-NH2 |
| Molecular Weight | 3206.9 |
| Formula | C147H245N51O30 |
| Sequence | RFGRFLRKIRRFRPKVTITIQGSARF-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Solublie in dilute acid and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | CATH-2 (chicken) MSDS_602bab93e52f7.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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