Matrix metalloproteases

Matrix metalloproteases (MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation.  Matrix metalloproteases are organized into six groups based on domain organization and substrate preference: collagenases (MMP-1, -8 and -13), gelatinases (MMP-2 and MMP-9), stromelysins (MMP-3, -10 and -11), matrilysin (MMP-7 and MMP-26), membrane-type (MT) MMPs (MMP-14, -15, -16, -17, -24 and -25) and other (MMP-12, -19, -20, -21, -23, -27 and -28),  MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. 

Further reading

Page-McCaw et al (2007) Matrix metalloproteinases and the regulation of tissue remodelling. Nat. Rev. Mol. Cell. Biol. 8, 221 PMID: 17318226

Löffek et al (2011) Biological role of matrix metalloproteinases: a critical balance.  Eur. Respir. J. 38(1) 191 PMID: 21177845

Quintero-Fabián (2019) Role of Matrix Metalloproteinases in Angiogenesis and Cancer. Front. Oncology 9 1370  PMID: 31921634