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Products
Pharmacology
Type
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- Technical support
- Resources
Deubiquitinating enzymes
Deubiquitinating enzymes (DUBs) are a group of proteases that catalyze the cleavage of protein-ubiquitin bonds. By removing these modifications, DUBs counteract the activity of ubiquitin ligases, which add ubiquitin molecules to target proteins. Uubiquitin specific proteases (USP) are the largest and best characterized of the DUB family. Deregulation of the ubiquitin-proteasome system (UPS) has been linked to numerous pathologies, including cancer and neurodegeneration.
Peptides
| Cat No. | Product Name | Activity |
|---|---|---|
| PI-280 | Q14 | USP30 inhibitor |
Small molecules
| Cat No. | Product Name | Activity |
|---|---|---|
| PI-001 | LDN 57444 | Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor |
| PI-080 | NSC 632839 | Ubiquitin isopeptidase inhibitor |
| PI-100 | P5091 | Ubiquitin specific protease 7 (USP7) inhibitor |
| PI-150 | PR 619 | Broad spectrum deubiquitinylating enzyme (DUB) inhibitor |
| PI-200 | TCID | Ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor |
| PI-240 | WP 1130 | Deubiquitinase (DUB) inhibitor |
Further reading
Reyes-Turcu et al (2009). Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Ann. Review Bochem. 78 363 PMID: 19489724
He et al (2016) The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics. Cell Biosci. 6 62 PMID: 28031783
Harrigan et al (2018) Deubiquitylating enzymes and drug discovery: emerging opportunities. Nat. Rev. Drug Discov. 17 57 PMID: 28959952
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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