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NNGH
Cat. No. PI-060
Structure:
N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid
Activity:
Matrix metalloproteinase 3 (MMP-3) inhibitor
NNGH is a potent and cell-permeable inhibitor of matrix metalloproteinase 3 (MMP-3, stromelysin 1, progelatinase). Inhibition of MMP-3 with NNGH significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-KB, AP-1, and MAPK in LPS-stimulated microglia, suggesting a role for MMP-3 in neuroinflammation. NNGH additionally shows broad spectrum inhibition activity at other MMPs and is cell permeable.
Zheng et al (2009) Matrix metalloproteinase-3 accelerates wound healing following dental pulp injury. Am. J. Pathol. 175(5) 1905 PMID: 19834065
Eum et al (2014) Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. Am. J. Physiol. Gastrointest. Liver Physiol. 306(11) G992 PMID: 24742991
Gonulalan et al (2019) A new perspective on evaluation of medicinal plant biological activities: The correlation between phytomics and matrix metalloproteinases activities of some medicinal plants. Saudi Pharm. J. 27(3) 446 PMID: 30976190
Related areas
All small molecules >
All matrix metalloprotease modulators >
All immunology research categories >
Technical Data
| Structure | N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid |
| CAS Number | 161314-17-6 |
| Molecular Weight | 316.37 |
| Formula | C13H20N2O5S |
| Sequence | N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid |
Solubility and Storage
| Solubility | Soluble in DMSO to 100 mM and in ethanol to 25 mM |
| Appearance | Off white solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | > 98% |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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